## Description

This column shows the predicted transcription factor binding sites that correlate with expression of the gene.

## Methods

The approach underlying this annotation is described in Segal, E. et al., Genome-wide discovery of transcriptional modules from DNA sequence and gene expression, Bioinformatics 19(Suppl 1), i273-i282 (2003). The analysis was performed on various pre-existing microarray datasets. A regulatory module is comprised of a set of genes predicted to be regulated by the same combination of DNA sequence motifs. Predictions are based on the co-expression of the set of genes in the module and on the appearance of common combinations of motifs in the upstream regions of genes assigned to the same module.

## Credits

Thanks to Eran Segal for providing the data analysis that forms the basis for this column.