The Genome Aggregation Database (gnomAD) v4 - Exome Coverage track shows how many times regions of the genomes were sequenced. This track includes several subtracks of average coverage metrics and sample percentage of coverage.
There is no gnomAD v4 genome coverage track because the genomes were unchanged from V3. There is no gnomAD v3 exomes track because v3 was a genome-only release.
Coverage was computed using all gnomAD 4 exome samples from their GVCFs. The gVCFs were produced using a 3-bin blocking scheme:
The coverage was binned by quality using the thresholds above and the median coverage value for each of the resulting coverage blocks was used to compute the coverage metrics presented in the browser. Coverage was computed for all callable bases in the genome (all non-N bases, minus telomeres and centromeres).
The Average/Median Sample Coverage tracks display the mean and median read depth of the samples at each base position. The details page shows calculated sample percentages for the range of sequence within the browser window.
The nX Coverage Percentage tracks display the percentage of samples whose read depth is at least 1X, 5X, 10X, 15X, 20X, 25X, 30X, 50X, and 100X at each base position. The details page shows calculated sample percentages for the range of sequence within the browser window.
The raw data can be explored interactively with the Table Browser, or the Data Integrator. For automated analysis, the data may be queried from our REST API, and the genome annotations are stored in files that can be downloaded from our download server, subject to the conditions set forth by the gnomAD consortium (see below). Coverage values for the genome are in bigWig files in the coverage/ subdirectory. Variant VCFs can be found in the vcf/ subdirectory.
The data can also be found directly from the gnomAD downloads page. Please refer to our mailing list archives for questions, or our Data Access FAQ for more information.
More information about using and understanding the gnomAD data can be found in the gnomAD FAQ site.
Thanks to the Genome Aggregation Database Consortium for making these data available. The data are released under the ODC Open Database License (ODbL) as described here.
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