Description

Like DNA, mature RNA molecules carry chemical modifications that influence their fate. The most abundant internal modification of mRNA is N&sup6;-methyladenosine (m6A), deposited by the METTL3/METTL14 writer complex onto adenosines that lie in a specific 5'-DRACH-3' sequence context (D = A/G/U, R = A/G, H = A/C/U). m6A and related modifications regulate pre-mRNA processing, nuclear export, mRNA decay, and translation, and are increasingly implicated in development and disease.

This collection groups together tracks related to RNA chemical modifications. The current tracks are:

• DRACH motif sites — every occurrence of the m6A consensus motif (DRACH) in MANE Select transcripts, projected onto the genome.
• Fetal M6A from Xiao 2019 — experimentally measured m6A peaks in fetal human tissues from Xiao et al. 2019.
• m6A-Atlas v2 sites — high-confidence base-resolution m6A sites compiled from 12 high-resolution detection technologies across 24 human cell lines and tissues, from m6A-Atlas v2.0 (Liang et al. 2024).

Display Conventions

Each subtrack uses its own colouring convention. See the individual track description pages for details.

Data Access

For automated download and analysis instructions, see the description page of each subtrack.

Credits

Thanks to Natacha Clairet and Guillaume Riviere for paper suggestions.